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IVM-CMS3 is the world’s most compact and affordable dual-mode intravital Confocal and Two-Photon microscope, providing versatile functionality in a single box. Having the Confocal laser units of IVM-C3 and the compact Two-Photon laser unit of IVM-MS3 with a one-switch mode changing feature, IVM-CMS3 provides comfortable multi-purpose use for intravital functional imaging and saves from unnecessary space and high costs.
IVIM Technology’s contract R&D service provides high-quality observations of cellular-level dynamics in various animal models. Dynamic 3D imaging of various cellular-level dynamics such as cell trafficking, cell-cell interaction, and cell-microenvironment interaction inside the living body in vivo will provide you a new insight in the processes of human disease development.
Intravital microscopy enables dynamic, 3D, cellular-level imaging of various biological processes in vivo. It enables scientists to directly verify hypothesis derived from ex vivo or in vitro observations in natural physiological microenvironments.
Using intravital microscopy, in vivo visualizations of gene expression, protein activity, cell trafficking, cell-cell / cell-microenvironment interactions, and various physiological responses to stimuli have been accomplished, providing novel insights, which have been impossible to obtain with conventional static 2D observation of ex vivo or in vitro samples.
However, up until now, individual users have had to improvise the required functions for each of the intravital imaging applications for the various organs with conventional standalone microscopes, which resulted in non-optimal performance for limited applicability.
The IntraVital Microscopy (IVM) systems from IVIM Technology, is a fully integrated system with optimized optical, mechanical, and electrical components to ensure best-in-class imaging performance for a wide range of in vivo intravital imaging applications.
The IVM systems (IVM-C/M/CM/MS) provide an all-in-one in vivo imaging solution with integrated physiological monitoring and support, anesthesia, along with state-of-the-art living tissue motion compensation for improved image quality. The software has been fully optimized to allow for rapid image acquisition, while image processing is accelerated by GPU-assisted parallel computing.
| Feature | Benefit |
| Integrated temperature support, and physiological monitoring | Ensures animal well-being throughout the imaging session, and consistency between animals within a study
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| Integrated inhaled anesthesia | Ensures ease of animal handling and consistent plane of anesthesia |
| Animal motion compensation | Provides enhanced image quality on organs which may be affected by respiratory motion
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| User friendly design – both software and hardware | Allows for ease of use, and reproducible results |
| 4-color simultaneous imaging | Confocal / Two-Photon Modes – Allows users to track the movement of several cells in vivo to better understand the biological processes being examined |
| Ultrafast rotating polygonal mirror scanner |
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| IVM-C3 (Confocal) | IVM-C is optimized for in vivo imaging experiments. It is specially equipped with four (4) different wavelength lasers and four (4) high-sensitivity confocal detectors. IVM-C is the optimal system to observe highly diverse, dynamic multi-cellular behaviors in living animals simultaneously with four (4) different fluorescence colors.
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| IVM-M3 (Two-Photon) | IVM-M is optimized for in vivo imaging experiments. Especially because it is equipped with a fully-automated tunable femtosecond (fs) pulse NIR laser system. IVM-M is the optimal system for users who need to conduct deeper-tissue imaging using less-scattering NIR wavelengths. The fs-laser system’s full control functionality is integrated with the two-photon imaging software for user convenience with various automated algorithms.
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| IVM-CM3 (Confocal & Two-Photon) | VM-CM is optimized for in vivo imaging experiments. Especially because both the confocal and two-photon microscopes are integrated into a single-box packaged system. IVM-CM provides the ultimate versatile functionality of the IVM-C and IVM-M in one system
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| IVM-MS3 (Two-Photon Smart Version) | IVM-MS is optimized for in vivo imaging experiments and is equipped with a new compact, high-efficiency femtosecond (fs) pulse laser module. Especially because it integrates a compact high-stability maintenance-free fs-pulse laser into a single box. The IVM-MS is the ideal solution for customers in need of a two-photon microscope with limited resources of space and budget.
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The various IVM models have the following optional add-on items:
The IVM series of systems have been designed to provide expandability and flexibility for highly diverse intravital imaging applications of various tissues and organs, including the brain, liver, spleen, kidney, pancreas, lung, heart, gastrointestinal tract, retina, skeletal muscle, bone marrow, peripheral lymph node, prostate, thymus, thyroid gland, adipose tissue, blood, and lymphatic vessels, etc.
In addition, to handle various imaging needs raised by researchers for a wide range of biomedical studies, detailed experimental protocols have been established for high-quality intravital image acquisition. Subsequent quantitative analysis of various cellular-level dynamics and physiological alterations have been established.
| Confocal Microscopy | Two-Photon Microscopy |
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