Optical contrast Agents

NiraWave Optical Contrast Agents by Viscover

Advance your optical imaging research with NiraWave optical imaging agents – novel dyes and nanomaterials, ideal for the study of vascular fine structure, disease-related vascular changes and tumors.

Visualize blood vessels with exceptional detail

NiraWave agents are designed to capitalize the most from your imaging device.

NiraWave C is the animal imaging formulation of the clinical indocyanine green agent that has been used for angiography (eye), organ perfusion, rheumatology diagnostics, and photodynamic therapy research
NiraWave M is a unique micellar formulation of the clinical ICG dye with a long circulation time and is perfectly suited for the study of vascular leakage in inflammation
NiraWave Rocker is an innovative nanoparticulate optical imaging agent optimized for visualization of primary tumors and metastases
NiraWave nano 780 is a nanoparticulate optical imaging agent developed for optical angiography that provides a broad excitation range, a high quantum yield, and the best possible tissue penetration

NiraWave™ C

NiraWave™ C is formulated from the clinically proven indocyanine green (ICG) agent for use in small animal imaging. It is a versatile dye that has been used for angiography of the eye, organ perfusion, rheumatology diagnostics, and photodynamic therapy research.

NiraWave™ C – the trusted standard from clinical practice:

Saves you the time by eliminating tedious dilution and formulation steps
Provides consistently reliable results
Serves as a reference contrast agent
Is hassle-free allowing you to focus on the experiment at hand
Indocyanine green has been clinically used for various applications:
angiography in opthalmology, organ perfusion, as well as rheumatology diagnostics based on vascular leakage

Download Data Sheet

NiraWave™ M

NiraWave™ M is an innovative micellar formulation of the clinically proven near-infrared fluorescence dye indocyanine green (ICG). Due to the unique formulation, NiraWave M exhibits a stronger fluorescence, higher aqueous stability and prolonged blood circulation time. It is ideal for optical angiography and is particularly suited for the visualization of vascular leakage in inflammation (e.g. in rheumatic diseases).

NiraWave™ M – the unique optical imaging agent:

Has a high apparent molecular weight
Stays confined within healthy blood vessels
Exits from fenestrated blood vessels, for example in inflammation

Apply NiraWave™ M to:

Study inflammatory processes, e.g. in rheumatic diseases
Benefit from the strong and long-lasting blood vessel contrast allowing studies of the microcirculation
Monitor therapeutic response

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NiraWave™ Rocker

NiraWave™ Rocker is a nanoparticulate near-infrared (NIR) fluorescence imaging agent optimized for visualization of primary tumors and metastases. Its accumulation in tumor cells via the rocker-switch mechanism as well as its strong fluorescence and high stability enable visualization of tumors in animal cancer models.

NiraWave™ Rocker – the leading optical imaging agent for tumor visualization:

Is based on a nanoparticle with a high intrinsic fluorescene intensity
Highlights primary and metastatic tumors
Exhibits stable fluorescence enabling longtime visualization of tumors

Applications:

Detect primary tumors and metastases based on its selective enrichment
Study tumor progression in tumor-bearing mouse models
Monitor therapeutic response

Downloads

Data Sheet

Application Sheet: Long Term Tumor Visualization

NiraWave™ nano 780

NiraWave™ nano 780 is a nanoparticulate optical imaging agent for the visualization of vascular fine structure as well as angiogenic processes in tumors and inflammation. It provides a broad excitation range, a high quantum yield and best possible tissue penetration due to fluorescence in the near-infrared range.

NiraWave™ nano 780 – the the nanoparticle optical imaging agent:

Exhibits a high Stokes-shift and high resistance towards bleaching
Is optimized for an extended circulation time
Enables a wide imaging time window
Accumulates in the liver and spleen

Applications:

Visualize the vascular fine structure
Study angiogenesis in tumors and inflammation

Download Data Sheet

NiraWave™ C

NiraWave C is formulated from the clinically proven indocyanine green (ICG) agent for use in small animal imaging. It is a versatile dye that has been used for angiography of the eye, organ perfusion, rheumatology diagnostics, and photodynamic therapy research.

NiraWave C – the trusted standard from clinical practice:

Saves you the time by eliminating tedious dilution and formulation steps
Provides consistently reliable results
Serves as a reference contrast agent
Is hassle-free allowing you to focus on the experiment at hand
Indocyanine green has been clinically used for various applications:
angiography in opthalmology, organ perfusion, as well as rheumatology diagnostics based on vascular leakage

Physico-chemical properties and structure

Molecular weight:

775 g mol ^-1

Emission wavelength:

820 nm

Excitation wavelength:

650 – 780 nm

Download Data Sheet

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Optical contrast Agents

NiraWave Optical Contrast Agents by Viscover

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